Focus on fosfomycin trometamol

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J Van Schoor

Abstract

Fosfomycin, a phosphonic acid derivative and a naturally-occurring antibiotic, was discovered in 1969 when it was successfully cultured from Streptomyces spp.1,2 Fosfomycin is in an antimicrobial class of its own and is structurally unrelated to any other agent currently approved for clinical use.3


Fosfomycin was initially developed as a calcium salt for oral use and a sodium salt for intravenous use.4 The tromethamine salt (also known as trometamol) is water soluble and provides markedly improved oral bioavailability compared to the calcium salt.4

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J Van Schoor, Amayeza Information Services

Amayeza Information Services, South Africa